Progesterone hypersensitivity is a rare condition in which an individual experiences an allergic or hypersensitive reaction to the hormone progesterone. The ovaries naturally produce this hormone and play a critical role in regulating the menstrual cycle, maintaining pregnancy, and supporting other reproductive functions. Progesterone is a hormone produced by the ovaries. It peaks just before menstruation. Georgina suffered from progesterone hypersensitivity, an allergic reaction to progesterone. Common symptoms include itching, swelling, and redness. In some, the symptoms can be severe, coughing, shortness of breath, and a severe allergic reaction called anaphylaxis. Medicines to reduce the production of progesterone are given as a remedy.
Symptoms of Progesterone Hypersensitivity
The symptoms can vary widely but often include:
- Skin Reactions: Hives, rashes, and itching, typically occurring in the luteal phase of the menstrual cycle (after ovulation and before menstruation).
- Respiratory Symptoms: Wheezing, shortness of breath, or other asthma-like symptoms.
- Systemic Reactions: Generalized swelling, joint pain, and in some cases, anaphylaxis (a severe, life-threatening allergic reaction).
- Reproductive Symptoms: Increased premenstrual symptoms like breast tenderness, mood swings, or bloating.
Diagnosis
Diagnosing progesterone hypersensitivity can be challenging and usually involves:
- Clinical History: Documentation of symptoms correlated with the menstrual cycle.
- Skin Testing: Intradermal testing with progesterone may be performed to observe a reaction.
- Hormone Challenge: Administering progesterone to see if it provokes symptoms.
Treatment
Treatment strategies may include:
- Hormonal Therapies: Such as suppressing ovulation with continuous oral contraceptives or GnRH analogs.
- Immunotherapy: Desensitization protocols are sometimes used.
- Symptomatic Treatment: Antihistamines, corticosteroids, and other medications to manage allergic reactions.
Prognosis
The condition is rare and varies in severity, but with appropriate management, many individuals can find relief from symptoms.
If you or someone you know suspects they may have progesterone hypersensitivity, it’s essential to consult a healthcare provider, particularly an allergist or immunologist, for proper evaluation and management.